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Domperidone is a dopamine antagonist which has antiemetic properties.
The antiemetic effect is caused by a combination of peripheral (gastrokinetics) and antagonist effect to the dopamine receptor at the chemoreceptor trigger zone (CTZ) in the area postrema at the outer part of the blood brain barrier.
Domperidone given by oral administration prolongs antral and duodenal contraction, enhance gastric emptying of liquid and semisolid form in healthy people and solid form in delayed gastric emptying patient, and increases lower esophageal sphincter pressure.
