Each gram of cream/gel/ointment contains: Mometasone furoate 1 mg.
Action
Mometasone furoate possesses an anti-inflammatory, antipruritic, and vasoconstrictive effects. The mechanism of action on how a topical steroid possesses an anti-inflammatory effect is generally unclear. It is predicted that corticosteroid may act through induction of phospholipase-A2 inhibitory proteins, collectively known as lipocortin. It is postulated that these proteins control the biosynthesis of inflammatory mediators such as prostaglandin and leucotrienes by inhibiting the release of their precursor (i.e. Arachidonic acid) from membrane phospholipids by Phospholipase-A2.
Indications/Uses
To relief inflammatory and pruritic manifestations of corticosteroid responsive dermatosis such as psoriasis and atopic dermatitis.
Dosage/Direction for Use
Apply a thin film to the affected area once daily or as recommended by the physician.
Do not use occlusive dressing.
Mesone cream 5 g and 10 g: The product can be used within 35 days after opened.
Mesone gel 10 g: The product can be used within 35 days after opened.
Mesone ointment 10 g: The product can be used within 35 days after opened.
Contraindications
Patients with rosaceae and ulcerative skin lesions.
Patients who are sensitive to Mometasone furoate, other corticosteroids, or any other component of this preparation.
Special Precautions
It is not for ophthalmic use.
Use with caution in pregnant and nursing women.
Discontinue application if irritation or sensitization occurs, and appropriate therapy should be administered.
If dermatologic infections occurs. this preparation should be administered in combination with appropriate antibacterial or antifungal agent. If the treatment hasn't shown any benefit. discontinue application until infection has been adequately controlled.
Use in infant and children may cause adrenal suppresion.
Systemic absorption of topical corticosteroid will be increased if extensive body surface areas are treated or if occlusive dressing is used. Pediatric patients may demonstrate greater susceptibility to topical corticosteroid-
induced hypothalamus-pituitary axis suppression and Cushing's syndrome than adult patients because of a larger skin surface area to body weight ratio. Chronic corticosteroid therapy may interfere with growth and development of children.
Corticosteroid therapy is applied only if any other less toxic drug is not effective.
Adverse Reactions
The following local adverse reactions have been reported infrequently with the use of topical corticosteroids: burning sensation, itching, irritation, dry skin, folliculitis, hypertrichosis, acneiform eruption, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration, secondary infection, skin atrophy, striae, and miliaria.
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