The P-gp inhibitors cyclosporine, dronedarone, erythromycin, or ketoconazole result in increased concentration of edoxaban and a dose reduction of 30 mg is required. Edoxaban should be used with caution with concomitant P-gp inducers (e.g. phenytoin, carbamazepine, phenobarbital or St John's Wort). Concomitant high dose ASA (325 mg) or chronic NSAIDs is not recommended.
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