Keppra Dosage/Direction for Use

The film-coated tablets must be taken orally, swallowed with a sufficient quantity of liquid and may be taken with or without food. After oral administration the bitter taste of levetiracetam may be experienced. The daily dose is administered in two equally divided doses.
Adults and Adolescents Older than 16 Years: The initial therapeutic dose is 500 mg twice daily. This dose can be started on the first day of treatment.
Depending upon the clinical response and tolerance, the daily dose can be increased up to 1,500 mg twice daily. Dose changes can be made in 500 mg twice daily increases or decreases every two to four weeks.
Elderly (65 Years and Older): Adjustment of the dose is recommended in elderly patients with compromised renal function.
Children: There are insufficient data to recommend the use of levetiracetam in children and adolescents under 16 years of age.
Renal Impairment: The daily dose must be individualised according to renal function. Refer to the table provided and adjust the dose as indicated. To use the dosing table, an estimate of the patient's creatinine clearance (CLcr) in mL/min is needed. The CLcr in mL/min may be estimated from serum creatinine (mg/dL) determination using the formula provided. (See equation and table.)


Click on icon to see table/diagram/image



Click on icon to see table/diagram/image


Hepatic Impairment: No dose adjustment is needed in patients with mild to moderate hepatic impairment. In patients with severe hepatic impairment, the creatinine clearance may underestimate the renal insufficiency. Therefore, a 50% reduction of the daily maintenance dose is recommended when the creatinine clearance is <70 mL/min.