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Use in Pregnancy & Lactation: 1) The contraction of fetus artery is reported in the study of terminal stage pregnant rats that this product was orally administered.
2) It is reported that the renal failure and continuous fetal circulation of a fetus occurred by administration (oral, injection, rectal infusion) of this product in late pregnancy.
3)The prolonged use of this product with large dose or to wide affected parts should be avoided in pregnant or some who may be pregnant and some in lactation as its safety during pregnancy and lactation has not yet been established.
4) In rat with this drug during late pregnancy, premature closure of the ductus arteriosus has been reported. In oral administration during late pregnancy (oral, injection, rectal infusion). Persistent fetal circulation (PFC) and fetus renal failure have been reported.
