KefenTech Mechanism of Action

Pharmacotherapeutic group: Antiinflammatory preparations, non-steroids for topical use.
Pharmacology: Pharmacodynamics: Mechanism of action: Ketoprofen is an inhibitor of both the cyclo-oxygenase and lipoxygenase pathways. In addition, ketoprofen is a powerful inhibitor of bradykinin (a chemical mediator of pain and inflammation).
Pharmacodynamic effects: Inhibition of prostaglandin synthesis provides for potent anti-inflammatory, analgesic and antipyretic effects. Lipoxygenase inhibitors appear to attenuate cell-mediated inflammation and thus retard the progression of tissue destruction in inflamed joints. Ketoprofen stabilises the lysosomal membranes against osmotic damage and prevents the release of lysosomal enzymes that mediate tissue destruction in inflammatory reactions.
Pharmacokinetics: Absorption: Ketoprofen can be applied topically in effective concentrations, but with very low plasma concentrations of drug. Therapeutic levels in the affected tissues provide relief from pain and inflammation.
Distribution: Ketoprofen is 95-99% bound to plasma proteins. Significant levels of ketoprofen have been found in tonsillar tissue and in the synovial fluid following systemic administration.
Biotransformation: Ketoprofen is extensively metabolised: approximately 60-80% of the product administered systemically is found in the form of metabolites in the urine.
Elimination: Elimination is rapid and takes place essentially via the renal route: 50% of the product administered systemically is excreted in the urine within 6 hours.