Increased plasma conc w/ strong CYP3A inhibitors (eg, amprenavir, atazanavir, boceprevir, clarithromycin, conivaptan, delavirdine, diltiazem, erythromycin, fosamprenavir, indinavir, itraconazole, ketoconazole, lopinavir, mibefradil, miconazole, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telaprevir, telithromycin, voriconazole & grapefruit or grapefruit juice). Decreased plasma conc w/ strong (eg, carbamazepine, enzalutamide, felbamate, nevirapine, phenobarb, phenytoin, primidone, rifabutin, rifampin, rifapentin & St. John's wort) & moderate (eg, bosentan, efavirenz, etravirine, modafinil & nafcillin) CYP3A inducers. Increased AUC
inf & C
max of midazolam. Increase therapeutic effect & ARs of P-gp substrates (eg, digoxin, dabigatran, colchicine) or BCRP (eg, pravastatin, rosuvastatin, sulfasalazine). Increased exposure of OCT1 transporter substrates (eg, metformin).