Hepagusan Mechanism of Action

Pharmacology: Inj: Heparin acts indirectly at multiple sites in both the intrinsic and extrinsic blood clotting systems to po­tentiate the inhibitory action of antithrombin III (heparin cofactor) on several activated coagulation factors, including thrombin (factor IIa) and factors IXa, Xa, XIa, and XIIa, by forming a complex with inducing a conformational change in the antithrombin III molecule. Inhibition of activated factor Xa interferes with thrombin generation and thereby inhibits the various actions of thrombin in coagulation. Heparin also accelerates the formation of an antithrombin III - thrombin complex, thereby inactivating thrombin and preventing the conversion of fibrinogen to fibrin; these actions prevent extension of existing thrombin.
Larger doses of heparin are required to inactivate thrombin than are required to inhibit thrombin formation. Heparin also prevents formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor by thrombin. Heparin has no fibrinolytic activity.
Topical Gel: Heparin is an anticoagulant that prevents the formation of clots in the blood and help breaks the clotting of blood that has formed.