Hepagusan

Hepagusan

heparin

Manufacturer:

Sanbe

Marketer:

Sanbe
Concise Prescribing Info
Contents
Heparin Na
Indications/Uses
Inj: Prophylaxis & treatment of venous thrombosis & pulmonary embolism. Treatment of arterial embolism. Prevention of coagulation in heart & arterial surgery, cerebral thrombosis. Anticoagulant in blood transfusions. Topical gel: Superficial phlebitis, excessive vena blockage, injuries during exercise & accident.
Dosage/Direction for Use
Inj Hemodialysis 7,500-12,500 IU; IV 5,000-10,000 IU 4 hrly by bolus or continuous infusion in NaCl or dextrose. SC Initially 5,000 IU IV bolus inj then 10,000 IU 8 hrly. Low-dose heparin prophylaxis Patient >40 yr undergoing abdominal or thoracic surgery 5,000 IU SC 2 hr pre-op then 5,000 IU SC 8-12 hrly w/o laboratory control. Topical gel Apply thinly in the affected area 2-3 times daily. May be applied in the gauze then cover the affected area.
Contraindications
Hypersensitivity. Inj: Haemorrhagic diatheses, GI tract ulcers, severe HTN (decompensated), CNS surgical procedures, suspected brain haemorrhage, endocarditis lenta, thyroid operation, suspected malignant tumor w/ risk of bleeding. Not to be given IM for possibility of hematoma. Severe liver, kidney & pancreatic disease as well as imminent abortus in anticoagulant therapy.
Special Precautions
Inj: Not for IM administration. Patients w/ disruptive ulcerative lesions, menstruation or hemostatic liver disease. Patients who will undergo surgery & post-op. Discontinue if coagulation test is too long or bleeding occurs. Closely monitor for thrombocytopenia. Patients w/ cardiac arrhythmia given high dose of benzyl alcohol. Pregnancy. Elderly. Topical gel: Not to be applied in mucous membranes or open wounds. Not to be rubbed or massaged in areas w/ thrombosis & thrombophlebitis condition.
Adverse Reactions
Inj: Local or generalized allergic reactions. Transient & reversible hair loss, thrombocytopenia, osteoporosis (long-term therapy). Headache, nausea, itching & increased body temp in anticoagulant therapy. Occurrence of hematoma in prophylaxis of thromboembolism.
Drug Interactions
Inj: Synergistic effect w/ ASA, dipirydamole, phenylbutazone, indometacin, sulfinpyrazone, probenecid, dextran, ethacrynic acid, dicumarol, cytostatic drugs, aspirin, NSAID, octylsalicylic acid, hydrochloroquine. Counteractive effect w/ antihistamines, digitalis prep, tetracycline, nicotine abuse, ascorbic acid.
MIMS Class
Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics) / Phlebitis & Varicose Preparations
ATC Classification
B01AB01 - heparin ; Belongs to the class of heparin group. Used in the treatment of thrombosis.
C05BA03 - heparin ; Belongs to the class of heparins or heparinoids used topically in antivaricose therapy.
Presentation/Packing
Form
Hepagusan inj 5,000 IU/mL
Packing/Price
5 mL x 10 × 1's (Rp829,250/boks)
Form
Hepagusan topical gel
Packing/Price
20 g x 1's (Rp46,150/boks)
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