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Applies only to single use presentation forms: GONAL-f must not be administered as a mixture with other medicinal products in the same injection, except lutropin alfa or combination of lutropin alfa and follitropin alfa for which studies have shown that co-administration dose not significantly alter the activity, stability, pharmacokinetics nor pharmacodynamic properties of the active substances.
Applies to all presentation forms: Concomitant use of GONAL-f with other medicinal products used to stimulate ovulation (e.g. hCG, clomiphene citrate) may potentiate the follicular response, whereas concurrent use of a GnRH agonist or antagonist to induce pituitary desensitisation may increase the dose of GONAL-f needed to elicit an adequate ovarian response. No other clinically significant medicinal product interaction has been reported during GONAL-f therapy.
