Glurenorm Drug Interactions

A number of drugs are known to influence glucose metabolism, possible interactions should therefore be taken into account by the physician.
Pharmacokinetic and pharmacodynamic drug-drug interactions with GLURENORM may alter the blood glucose lowering effect. Sulfonylureas are extensively bound to plasma proteins and therefore can be displaced by co-medications also exhibiting high protein binding.
The concomitant use of the following substances may increase the hypoglycaemic effect of GLURENORM: ACE inhibitors, allopurinol, analgesics and nonsteroidal antiphlogistics, antifungals, chloramphenicol, clarithromycin, clofibrate, coumarin anticoagulants, fluoroquinolones, heparin, MAO inhibitors, sulfinpyrazone, sulfonamides, tetracyclines and tricyclic antidepressants, cyclophosphamide and derivatives, insulin and other oral antidiabetics with and without intrinsic risk of hypoglycaemia.
Beta-receptor blocking agents, other sympatholytics (including clonidine), reserpine and guanethidine may possibly enhance the hypoglycaemic effect and also mask symptoms of hypoglycaemia.
The concomitant use of the following substances may reduce the hypoglycaemic effect of GLURENORM: aminoglutethimide, corticosteroids, diazoxide, oral contraceptives, sympathomimetics, rifamycins, thiazide and loop diuretics, thyroid hormones, glucagon, phenothiazines and nicotinic acid.