Increased hypoglycaemic effect w/ ACE inhibitors, allopurinol, analgesics & nonsteroidal antiphlogistics, antifungals, chloramphenicol, clarithromycin, clofibrate, coumarin anticoagulants, fluoroquinolones, heparin, MAOIs, sulfinpyrazone, sulfonamides, tetracyclines & TCAs, cyclophosphamide & derivatives, insulin & other oral antidiabetics w/ & w/o intrinsic risk of hypoglycaemia. β-receptor blocking agents, other sympatholytics (including clonidine), reserpine & guanethidine may enhance the hypoglycaemic effect & mask symptoms of hypoglycaemia. Reduced hypoglycaemic effect w/ aminoglutethimide, corticosteroids, diazoxide, OCs, sympathomimetics, rifamycins, thiazide & loop diuretics, thyroid hormones, glucagon, phenothiazines, nicotinic acid, barbiturates, rifampicin & phenytoin. H
2 receptor antagonists (cimetidine, ranitidine) & alcohol may reduce or enhance hypoglycaemic effects.
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