Gefitero Dosage/Direction for Use

Treatment with GEFITERO should be initiated and supervised by a physician experienced in the use of anticancer therapies.
The recommended dose of GEFITERO is one 250 mg tablet once a day, taken with or without food. If a dose of GEFITERO is missed, it should be taken as soon as the patient remembers. If it is less than 12 hours to the next dose, the patient should not take the missed dose. Patients should not take a double dose (two doses at the same time) to make up for a forgotten dose.
Where dosing a whole tablet is not possible, such as patients who are only able to swallow liquids, tablets may be administered as a dispersion in water. The tablet should be dropped into half a glass of drinking water (non-carbonated), without crushing, and the glass stirred until the tablet has dispersed (approximately 15 minutes) and the contents subsequently drunk immediately. The glass should be rinsed with a further half glass of water and the contents drunk. The liquid can also be administered via a nasogastric tube.
GEFITERO is not recommended for use in children or adolescents as safety and effectiveness in these patient populations has not been studied.
No dosage adjustment is required on the basis of patient age, body weight, gender, ethnicity or renal function or in patients with moderate to severe hepatic impairment due to liver metastases.
Dosage adjustment: Patients with poorly tolerated diarrhea or skin adverse drug reactions may be successfully managed by providing a brief (up to 14 days) therapy interruption followed by reinstatement of the 250 mg dose (see ADVERSE REACTIONS).