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Pharmacology: GAFORIN is an 8-methoxy fluoroquinolone antiinfective for topical ophthalmic use.
The antibacterial action of Gatifloxacin results from inhibition of DNA gyrase and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division.
Resistance to Gatifloxacin in vitro develops via multiple-step mutations. Resistance to Gatifloxacin in vitro occurs at a general frequency of between 1x10-7 to 10-10.
