As a phosphate-binding agent for use in the control of hyperphospatemia in chronic renal failure patients on haemodialysis or continuous ambulatory peritoneal dialysis (CAPD).
For oral use.
Adults, including Elderly (>65 years): Fosrenol should be taken with or immediately after food, with the daily dose divided between meals. The tablets should be chewed and not swallowed whole. The dose of Fosrenol should be titrated every 2-3 weeks until an acceptable serum phosphate level is reached. Control of serum phosphate level has been demonstrated at doses starting 750 mg. The maximum daily dose studied, in a limited number of patients is 3750 mg. Patients who respond to lanthanum therapy usually achieve acceptable serum phosphate levels at doses 1500-3000 mg lanthanum/day.
Hypersensitivity to lanthanum carbonate hydrate or to any of the excipients. Hypophosphatemia.
Patients with acute peptic ulcer, ulcerative colitis, Chron's disease or bowel obstruction were not included in clinical studies with Fosrenol. No data is available in patients with hepatic impairment. Caution should be exercised in these patients and monitoring liver function may be required. Patients with renal insufficiency may develop hypocalcemia. Serum calcium levels should, therefore, be monitored at regular intervals for this patient population and appropriate supplements given. The risk/benefit for longer-term administration (>2 years) should be carefully considered as experience with therapy beyond 2 years is limited.
Gastrointestinal reactions (eg, abdominal pain, constipation, diarrhoea, flatulence, nausea and vomiting).
Fosrenol may increase gastric pH. Therefore, it is recommended that compounds that are known to interact with antacids should not be taken within 2 hrs of dosing with Fosrenol (eg, chloroquine, hydroxychloroquine and ketoconazole). Interactions with drugs eg, tetracycline, doxycycline and floxacins are theoretically possible. Therefore, it is recommended that they are not taken within 2 hrs of dosing Fosrenol.
V03AE03 - lanthanum carbonate ; Belongs to the class of drugs used in the treatment of hyperkalemia and hyperphosphatemia.
Fosrenol chewable tab 500 mg
45's (Rp810,000/pak)
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