Folimid Drug Interactions

Chronic use of loop diuretics may result in thiamine deficiency. Substances in food (e.g. sulfate, caffeine) may inactive thiamine. Although the clinical importance is unknown, thiamin reportedly may enhance the effect of neuromuscular blocking agents.
Probenecid may inhibit the absorption of riboflavin and also inhibit renal tubular secretion of riboflavin. Use of oral contraceptive agents may result in decreased serum levels of riboflavin.
Women, who are taking folic acid supplements, especially if they are current or former users of oral contraceptives, are at risk for lower plasma zinc concentrations.
The use of oral contraceptives may increase vitamin B₆ requirements. Chronic and excessive use of alcoholic beverages can result in vitamin B₆ deficiency.
Metformin may decrease the absorption of vitamin B₁₂; this possible effect may be reversed with oral calcium supplementation. Folic acid may work synergistically with vitamin B₁₂ in lowering homocysteine levels.
Supplementary vitamin D should be used cautiosly in those on Digoxin or any cardiac Glycoside. Hypercalcemia in those on Digoxin may precipitate cardiac arrhythmias.
Broad-spectrum antibiotics may sterilize the bowel and decrease the vitamin K₁ contribution to the body by the intestinal microflora. Cephalosporins containing side chains of N-methylthiotetrazole or methylthiadizole can cause vitamin K deficiency and hypoprothrombinemia.
Vitamin K₁ can antagonize the effect of Warfarin; therefore the use of Warfarin should be avoided, unless specifically prescribed by physician.
Antibiotics may decreased the biotin contribution to the body made by microflora of the large intestine.
No interactions between DHA and Aspirin, other NSAIDs (nonsteroidal anti-inflammatory drugs) or herbs, such as Allium sativum (garlic) have been reported. Such interactions, if they occured, might be manifested by nose-bleeds and increased susceptibility to bruising.