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Capsule: In the cases of accidental or non-accidental overdose, it may cause irritation eg, pyrosis, stomachache, nausea, vomiting and diarrhea. There are no serious side effects or toxic symptoms reported, even in patients treated with very high doses of NAC. However, it is advisable to consult the physician in any case of overdoses.
Granules: 600 mg: No cases of overdose have been reported with respect to oral administration of acetylcysteine.
Symptoms: Overdose can cause gastrointestinal symptoms such as nausea, vomiting and diarrhea.
Treatment: There are no specific antidotic treatments; overdose therapy is based on symptomatic treatment.
Solution for inhalation: No particular toxic signs and symptoms have been observed, even in patients treated with high doses of NAC by systemic route. Very high doses of NAC by topical administration could produce an excessive and massive liquefaction of the mucopurulent secretions, particularly in subjects with inadequate coughing reflex of expectoration, in whom it may be necessary to use mechanical methods of bronchial suction.
