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Salbutamol inhalation solution may cause a fine tremor of skeletal muscle in some patients, usually the hands are most obviously affected. This effect is common to all beta-adrenergic stimulants.
In patients who are unusually sensitive to beta-adrenergic stimulants, peripheral vasodilatation and a compensatory small increase in heart rate may occur. There have been very rare reports of transient muscle cramps.
Hypersensitivity reactions including angioedema, urticaria, bronchospasm, hypotension and collapse have been reported very rarely. As with other inhalation therapy, the potential for paradoxical bronchospasm should be kept in mind. If it occurs, the preparation should be discontinued immediately and alternative therapy instituted.
As with other inhalation therapy, the potential for paradoxical bronchospasm may occur with an immediate increase in wheezing after dosing. This should be treated immediately with an alternative presentation or a different fast acting inhaled bronchodilator. Salbutamol inhalation solution should be discontinued immediately, the patient assessed, and if necessary alternative therapy instituted.
Potentially serious hypokalaemia may result from beta-2-agonist therapy. As with other beta-2 agonists hyperactivity has been reported rarely in children. Mouth and throat irritation may occur with inhaled salbutamol.
