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Instructions for Use and Handling: Injection: A solution for injection is prepared adding 5 mL of 0.9% sodium chloride for intravenous use to the vial with esomeprazole. The reconstituted solution should be inspected visually for particulate matter and discoloration prior to administration. Only clear solution should be used.
Infusion: A solution for infusion is prepared by dissolving the content of one vial with esomeprazole in up to 100 mL of 0.9% sodium chloride for intravenous use.
Infusion 80 mg: A solution for infusion is prepared by dissolving the content of two vials with esomeprazole 40 mg in up to 100 mL of 0.9% sodium chloride for intravenous use. The reconstituted solution should be inspected visually for particulate matter and discoloration prior to administration. Only clear solution should be used.
Incompatibilities: The degradation of reconstituted solution is highly pH dependent and the product must therefore only be reconstituted in the specific volume of 0.9% sodium chloride for intravenous use. The reconstituted solution should not be mixed or co-administration in the same infusion set with any other drug.
