The symptoms described in connection with deliberate Esomeprazole overdose (limited experience of doses in excess of 240 mg/day) are transient. Single oral doses of 80 mg Esomeprazole and intravenous doses of 308 mg Esomeprazole over 24 hours were uneventful. No specific antidote is known. Esomeprazole is extensively bounded plasma protein therefore not readily dialyzable. As in any case of overdose, treatment should be symptomatic and general supportive measures should be utilized.
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