Erbitux

Cetuximab

Patients w/ epidermal growth factor receptor (EGFR)-expressing RAS wild-type metastatic CRC, in combination w/ chemotherapy or in patients who have failed oxaliplatin- & irinotecan-based therapy & who are intolerant to irinotecan. Patients w/ squamous cell cancer of the head & neck, in combination w/ radiation therapy for locally advanced disease or in combination w/ platinum-based chemotherapy for recurrent &/or metastatic disease.

Prior to 1st infusion, patient must receive premed w/ an antihistamine & a corticosteroid at least 1 hr prior to therapy. Initially 400 mg/m² in 120-min IV infusion once wkly. Subsequent wkly doses: 250 mg/m² for 60 min once wkly. Max infusion rate: 10 mg/min.

Severe hypersensitivity (grade 3 or 4). Combination w/ oxaliplatin-containing chemotherapy in patients w/ mutant RAS metastatic colorectal cancer (mCRC) or unknown RAS mCRC status. Consider concomitant use w/ chemotherapeutic agents or radiation therapy.

Severe infusion-related reactions including anaphylactic reactions; history of allergy to red meat or tick bites or +ve IgE Ab test results; monitor especially in patients w/ reduced performance status & pre-existing cardiopulmonary disease. Discontinue use if ILD is diagnosed. Interrupt treatment in case of severe skin reaction (≥grade 3). Interrupt or discontinue treatment if ulcerative keratitis is confirmed. Not be used for CRC patients whose tumours have RAS mutations or unknown status. Determine serum electrolyte levels prior to & periodically during treatment; electrolyte repletion is recommended. Combination w/ platinum-based chemotherapy increased risk of severe neutropenia which may lead to subsequent infectious complications eg, febrile neutropenia, pneumonia or sepsis. Take into account CV & performance status of the patient & concomitant administration of cardiotoxic compd eg, fluoropyrimidines. History of keratitis, ulcerative keratitis or severe dry eye. Contact lens use is a risk factor for keratitis & ulceration. Patients presenting w/ Hb <9 g/dL; leukocyte count <3,000/mm³; ANC <1,500/mm³; platelet count <100,000/mm³. May affect ability to drive & use machines. Pregnancy. Do not breast-feed during treatment & for 2 mth after the last dose. Childn <18 yr. Elderly ≥75 yr.

Hypomagnesaemia; increased liver enzyme levels (ASAT, ALAT, AP); skin reactions; mild or moderate infusion-related reactions, mucositis. Dehydration, hypocalcaemia, anorexia; headache; conjunctivitis; diarrhoea, nausea, vomiting; severe infusion-related reactions, fatigue. ILD; SJS, TEN.

Increased frequency of severe leukopenia or neutropenia w/ platinum-based chemotherapy. Increased frequency of cardiac ischaemia including MI, CHF & hand-foot syndrome (palmar-plantar erythrodysaesthesia) w/ fluoropyrimidines. May increase frequency of severe diarrhoea w/ capecitabine & oxaliplatin.

Targeted Cancer Therapy

L01FE01 - cetuximab ; Belongs to the class of EGFR (Epidermal Growth Factor Receptor) inhibitors. Used in the treatment of cancer.

G