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Overdosage with Valproic Acid can cause drowsiness, heart block, and coma. Because Valproic Acid is absorbed quickly, the success of gastric emptying depends greatly on the time since administration. General supportive therapy can be done with special attention given to maintaining adequate bladder emptying.
Naloxone has been reported to reverse the effects of central nervous system depression due to an overdose of Valproic Acid. This drug must be used cautiously because Naloxone theoretically could reverse the antiepileptic effects of Valproic Acid.
