Combivent Side Effects

Many of the listed undesirable effects can be assigned to the anticholinergic and beta₂-sympathomimetic properties of COMBIVENT. As with all inhalation therapy, COMBIVENT may show symptoms of local irritation. Adverse drug reactions were identified from data obtained in clinical trials and pharmacovigilance during post approval use of the drug.
The most frequent side effects reported in clinical trials were headache, throat irritation, cough, dry mouth, gastrointestinal motility disorders (including constipation, diarrhoea and vomiting), nausea, and dizziness.
Immune System Disorders: Anaphylactic reaction, hypersensitivity.
Metabolism and Nutrition Disorders: Hypokalaemia.
Psychiatric Disorders: Nervousness, mental disorder.
Nervous System Disorders: Headache, tremor, dizziness.
Eye Disorders: Accommodation disorder, corneal oedema, glaucoma, increased intraocular pressure, mydriasis, blurred vision, eye pain, conjunctival hyperaemia, halo vision.
Cardiac Disorders: Arrhythmia, atrial fibrillation, myocardial ischaemia, palpitations, supraventricular tachycardia, tachycardia.
Respiratory, Thoracic and Mediastinal Disorders: Cough, dysphonia, dry throat, bronchospasm, paradoxical bronchospasm, laryngospasm, pharyngeal oedema.
Gastrointestinal Disorders: Dry mouth, nausea, throat irritation, diarrhoea, vomiting, constipation, gastrointestinal motility disorder, mouth oedema, stomatitis.
Skin and Subcutaneous Tissue Disorders: Skin reactions such as rash, pruritus, urticaria; angioedema; hyperhidrosis.
Musculoskeletal and Connective Tissue Disorders: Muscle spasms, muscular weakness, myalgia.
Renal and Urinary Disorders: Urinary retention.
General Disorders and Administration Site Conditions: Asthenia.
Investigations: Blood pressure diastolic decreased, Blood pressure systolic increased.