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Adults and children weighing ≥30 kg: Usual recommended daily dose is 50-100 mg given orally, twice daily.
Children weighing ≤30 kg: 1.5-3 mg/kg body weight twice daily in divided doses. For more severe or intractable infections, the dosage may be increased up to 200 mg, given twice daily. Dosage should be adjusted according to the age, body weight, and condition of patient. More Severe or Intractable Infections: Up to 6 mg/kg body weight twice daily in divided doses as twice daily.
Typhoid fever in children: 10-15 mg/kg BB/day for 2 weeks.
Patients with impaired renal function require dosage modification depending on the degree of impairment.
The recommended dosage is 75% of the standard dosage (i.e. 300 mg daily) when creatinine clearance is between 21-60 mL/min or for patients on renal hemodialysis.
The recommended dosage is 50% of the standard dosage (i.e. 200 mg daily) when creatinine clearance is <20 mL/min or for patient on continuous ambulatory peritoneal dialysis (CAPD).
For uncomplicated cervical/urethral gonorrhea, a single dose of 400 mg is recommended.
