Cefacef Adverse Reactions

Cefacef is generally well tolerated. The majority of adverse reactions were transient and self-eliminating naturally.
Shock: Adequate caution in administration should be used as shock symptoms may rarely occur. If any related signs or symptoms e.g. feeling unwell, oral cavity discomfort, stridor, dizziness, abnormal urge to defecate, tinnitus or diaphoresis occur, CEFACEF 200 must be discontinued immediately.
Hypersensitivity: If signs of hypersensitivity reactions e.g. rash, urticaria, erythema, pruritus or fever occur, CEFACEF 200 should be discontinued and appropriate measures should be taken.
Haematologic: Granulocytopenia, or eosinophilia, and thrombocytopenia may occur. CEFACEF 200 should be discontinued if any of these abnormalities is found. It has been reported that haemolytic anemia has occurred with other cephems.
Hepatic: Infrequently, an increase in ALT, AST, or alkaline phosphatase may occur.
Renal: Periodic monitoring of renal function is recommended as serious renal impairment e.g. acute renal insufficiency, may occur. If any of these abnormalities are found, discontinuation of CEFACEF 200 and other appropriate measures should be taken.
Digestive: In rare instances, a serious colitis e.g. pseudomembranous colitis, manifested by blood in stool may occur. Abdominal pain or frequent diarrhea requires appropriate measures, including prompt withdrawal of CEFACEF 200. Infrequently, vomiting, diarrhea, abdominal pain, stomach discomfort, heartburn or anorexia and rarely nausea, feeling of enlarged abdomen or constipation may occur.
Respiratory: In rare instances, interstitial pneumonia or PIE syndrome, manifested by fever, cough, dyspnea, abnormal chest x-ray or eosinophilia may occur. If any such symptoms occur, CEFACEF 200 should be immediately discontinued and appropriate treatment e.g. giving adrenocorticoid hormones should be taken.
Alteration in bacterial flora: Rarely, stomatitis or candidiasis may occur.
Vitamin deficiencies: Rarely, vitamin K deficiencies (e.g. hypoprothrombinemia or bleeding tendencies) or vitamin B group deficiencies (e.g. glositis, stomatitis, anorexia or neuritis) may occur.
Others: Rarely, headache or dizziness may occur.
Influences on laboratory values: False-positive results may occur with urine sugar tests using Benedict's solution, Fehling's solution, and Clinitest. False-positive results have not been reported with test-tape. A positive direct Coombs test may occur.