Capribose Dosage/Direction for Use

The dosage must be adjusted by the doctor to suit each patient, because efficacy and tolerability vary from one individual to another.
Unless otherwise prescribed, the recommended dosage is as follows: Initially 3 x 1 tablet of 50 mg CAPRIBOSE/day or 3 x ¹/₂  tablet of 100 mg CAPRIBOSE/day. Subsequently 3 x 2 tablet of 50 mg CAPRIBOSE/day or 3 x 1 tablet of 100 mg CAPRIBOSE/day up to 3 x 2 tablet of 100 mg CAPRIBOSE/day.
Doses may be increased after 4-8 weeks, and if patients show an inadequate clinical response in the later course of the treatment. If distressing complaints develop in spite of strict adherence to the diet the dose should not be increased further, and if necessary should be somewhat reduced. The average dose is 300 mg CAPRIBOSE/ day (corresponding to 2 tablets of CAPRIBOSE 50 or 1 tablet CAPRIBOSE 100, 3 times daily).
Elderly (> 65 years): No alteration of dosage or dosing frequency is recommended with regard to the age of the patients.
Hepatic Impairment: There is no dose adjustment for patients with a history of impaired liver function.
Administration: CAPRIBOSE is only effective if swallowed whole with a little liquid directly before meals or chewed with the first mouthful of meal.
No limit to the length of time for which CAPRIBOSE can be used is envisaged. The limitation on dosage is due to the secondary effects of carbohydrate malabsorption, in particular distention, flatulence, and loose stools. Some adaptation to these effects occurs in the first few weeks of use. The optimal therapeutic dose is established by minimizing whilst reducing postprandial glycaemic rises.