Bicorsan Mechanism of Action

Pharmacology: Bronchodilative Activity: The bronchodilation activity of Procaterol HCl Hemihydrate is comparable or more potent than Isoproterenol and more potent than Salbutamol sulfate and Orciprenaline sulfate.
Duration of Bronchodilative Activity: Procaterol HCl Hemihydrate had a longer duration of broncholative action than isoproterenol, trimetoquinol, Orciprenaline sulfate, or Salbutamol sulfate.
Selectivity to β₂-adrenergic receptors (Organ selectivity): The selectivity of Procaterol HCl Hemihydrate for β₂-adrenergic receptors in the respiratory system was greater than that for such receptors in the cardiovascular system, as compared to Isoproterenol, Trimetoquinol, Orciprenaline sulfate and Salbutamol sulfate.
Anti Allergic Activity: Procaterol HCl Hemihydrate exhibits hypo-allergenic effects by inhibiting increased antibody-induced respiratory resistance, the PCA reaction, and histamine release from sensitized lung tissues in guinea pigs and rats, as well as allergen-induced skin reactions and increases in asthmatic responses to allergen inhalation in bronchial asthma patients, as compared to Isoproterenol, Trimetoquinol, Orciprenaline sulfate, and Salbutamol sulfate. The drug also inhibited allergen-induced, delayed-type, and immediate-type bronchial responses.
Effects on Respiratory Tract System: Procaterol HCl Hemihydrate accelerates ciliary activity in the respiratory tract.
The Inhibitory Effect On The Incidence of Asthma Is Triggered By Exercise: Procaterol HCl Hemihydrate suppresses asthma attacks triggered exercise in patients with bronchial asthma.
Effects on Respiratory Tract Hypersensitivity: Procaterol HCl Hemihydrate inhibits the hypersensitivity of the respiratory tract.
Effects On Increased Vascular Permeability: Procaterol HCl Hemihydrate inhibits the acceleration of vascular permeability and the formation of edema due to various inflammatory agents, with the same potential as Isoproterenol. Procaterol also inhibits lung edema triggered by inhalation of histamine with greater potential than Salbutamol sulfate.
Effect on Cough: Procaterol HCl Hemihydrate inhibits substance-induced cough in upper respiratory tract infections.