Berodual Use In Pregnancy & Lactation

Pregnancy: Preclinical data, combined with available experience in humans, have shown no ill-effects in pregnancy of fenoterol or ipratropium. Nonetheless, the usual precautions regarding the use of drugs during pregnancy, especially during the first trimester should be exercised.
The inhibitory effect of Berodual on uterine contraction should be taken into account.
Lactation: Preclinical studies have shown that fenoterol hydrobromide is excreted into breast milk.
It is not known whether ipratropium is excreted in breast milk. But it is unlikely that ipratropium would reach the infant to an important extent, especially when taken by aerosol. However, because many drugs are excreted in breast milk, caution should be exercised when Berodual is administered to a nursing woman.
Fertility: Clinical data on fertility are not available for the combination of ipratropium bromide and fenoterol hydrobromide. Preclinical studies performed with the individual components, ipratropium bromide and fenoterol hydrobromide, showed no adverse effect in fertility (see Toxicology).