Anhisan

Anhisan

nicardipine

Manufacturer:

Sanbe

Marketer:

Sanbe
Concise Prescribing Info
Contents
Nicardipine HCl
Indications/Uses
Emergency treatment of acute hypertensive crises during surgery. Hypertensive emergencies.
Dosage/Direction for Use
Emergency treatment of acute hypertensive crisis during surgery 0.01-0.02% IV drip infusion (equiv 0.1-0.2 mg/mL) at a rate of 2-10 μg/kg/min until the desired BP value is reached. Rapid BP reduction 10-30 μg/kg IV inj. Hypertensive emergency 0.01-0.02% IV drip infusion (equiv 0.1-0.2 mg/mL) at a rate of 0.5 μg/kg/min until the desired BP value is reached.
Contraindications
Hypersensitivity. Patients recovering w/ incomplete hemostasis following intracranial bleeding; increased intracranial pressure in acute stroke in the brain.
Special Precautions
Gradual dose reduction & carefully control BP after discontinuation of treatment. Aortic stenosis. Closely monitor BP & heart rate. Discontinue use if hypotension occurs, norepinephrine should be given if rapid recovery is needed. Change inj site if pain or redness appear. Patients in post-op monitoring period after open heart surgery may experience circulatory failure. Renal or hepatic dysfunction. Pregnancy & women suspected of being pregnant. Not recommended during lactation. Infants & childn. Elderly.
Adverse Reactions
Tachycardia, facial redness. Paralytic ileus, hypoxemia, anginal pain, thrombocytopenia, impaired liver function & jaundice.
Drug Interactions
Increased AUC w/ HIV-PIs, saquinavir, ritonavir. Increased blood conc & efficacy w/ ritonavir. Increased hypotensive effects w/ other hypotensive drugs, fentanyl, cimetidine, tandospirone citrate. Increased hypotensive & negative inotropic effect w/ β-blockers eg, propranolol. Decreased renal clearance & increase blood conc of digoxin. May inhibit the enzyme P450 w/ immunosuppresants eg, ciclosporin, tacrolimus hydrate. May accelerate the metabolism of Ca antagonists as rifampicin induces metabolism of drug enzyme in the liver. Hypercalcemia may occur w/ dantrolene Na. Increased effect of muscle relaxants eg, pancuronium Br, Vecuronium Br. Nitroglycerin.
MIMS Class
Calcium Antagonists
ATC Classification
C08CA04 - nicardipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Anhisan inj 1 mg/mL
Packing/Price
10 mL x 10 × 1's (Rp2,050,000/boks)
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