General anaesth Adult Induction: 0.5-1 mcg/kg/min as infusion, w/ or w/o an initial bolus inj of 1 mcg/kg over not <30 sec. Maintenance in ventilated patients: Rate can be titrated upward in 25-100% increments or downward in 25-50% decrements, every 2-5 min to attain the desired level of μ-opioid response. Spontaneous breathing anaesthetized patients w/ a secured airway: Initially 0.04 mcg/kg/min as infusion. Discontinuation/continuation into immediate post-op: Infusion rate should initially be decreased to a rate of 0.1 mcg/kg/min in patients who are breathing spontaneously.
Childn 1-12 yr Maintenance: 0.25 mcg/kg/min as infusion.
Cardiac anaesth Induction: 1 mcg/kg/min. Maintenance: Rate can be titrated upward in 25-100% increments or downward in 25-50% decrements, every 2-5 min according to patient need.
Intensive care Initially 0.1-0.15 mcg/kg/min, may be titrated in increments of 0.025 mcg/kg/min.
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