Must not be administered as an IV push or bolus inj. Do not co-administer any other medicinal products through the same infusion line. Immediately interrupt administration in case of serious infusion-related or hypersensitivity reaction. Patients w/ history of infusion-related reactions &/or hypersensitivity may be pre-medicated (eg, antihistamine) before infusion. Not recommended in combination w/ biologic therapies. Has not been studied in patients w/ severe active CNS lupus or severe active lupus nephritis; patients w/ history of primary immunodeficiency. Increased risk of resp infections & herpes zoster. Caution in patients w/ chronic infection, history of recurrent infections, or known risk factors for infection. Do not initiate treatment in patients w/ any clinically significant active infection until the infection resolves or is adequately treated; patients w/ active TB. Complete all appropriate immunisations according to current immunisation guidelines prior to initiating therapy. Avoid concurrent use of live or attenuated vaccines. Consider individual benefit-risk in patients w/ known risk factors for the development or reoccurrence of malignancy. Exercise caution when considering continuing therapy for patients who develop malignancy. Pregnancy & lactation. Safety & efficacy in childn & adolescents <18 yr have not yet been established.