Pariet Dosage/Direction for Use

Adults/elderly: Duodenal Ulcer, Gastric Ulcer, Stomal Ulcer & Reflux Esophagitis: The usual adult dose is 10 mg of rabeprazole sodium administered orally once daily. However, the dosage may be increased up to 20 mg orally once a day depending on the severity of symptoms. For the treatment of gastric ulcer, stomal ulcer and reflux esophagitis, the usual administration should be restricted up to 8 weeks, and for duodenal ulcer, 6 weeks.
For patients suffering from reflux esophagitis who have not healed after 8 weeks of proton pump inhibitor treatment, a 10 mg or 20 mg dose of rabeprazole sodium may be administered orally twice daily for an additional 8 weeks. However, a twice daily 20 mg dose should only be administered to patients with severe mucosal injury.
Gastro-Esophageal Reflux Disease Long-Term Management (GERD Maintenance): For long-term management, a maintenance dose of PARIET 10 mg or 20 mg once daily can be used depending upon patient response.
Symptomatic Treatment of Moderate to Very Severe Gastro-Esophageal Reflux Disease (Symptomatic GERD): 10 mg once daily in patients without esophagitis. If symptom control has not been achieved during four weeks, the patient should be further investigated. Once symptoms have resolved, subsequent symptom control can be achieved using an on-demand regimen taking 10 mg once daily when needed.
Zollinger-Ellison Syndrome: The dose varies with the individual patient. A starting dose of 60 mg daily, and doses up to 100 mg once daily, or 60 mg twice daily have been used. Some patients may require divided doses. Dosing should continue for as long as clinically necessary. Some patients with Zollinger-Ellison syndrome have been treated continuously for up to one year.
Eradication of H. pylori: Patients with H. pylori infection should be treated with eradication therapy. The following combination given for 7 days is recommended: PARIET 20 mg twice daily + clarithromycin 500 mg twice daily and amoxicillin 1 g twice daily.
PARIET 10 mg twice daily + clarithromycin 200 mg twice daily and amoxicillin 750 mg twice daily.
If the H. pylori eradication with the three-drug regimen of proton pump inhibitor, amoxicillin and clarithromycin fails, the following combination given for 7 days as an alternative treatment is recommended: PARIET 10 mg twice daily + metronidazole 250 mg twice daily and amoxicillin 750 mg twice daily.
For indications requiring once daily treatment, PARIET tablets should be taken in the morning, before eating; and although neither the time of day nor food intake was shown to have any effect on rabeprazole sodium activity, this regimen will facilitate treatment compliance.
Patients should be cautioned that the PARIET tablets should not be chewed or crushed, but should be swallowed whole.
Renal and hepatic impairment: No dosage adjustment is necessary for patients with renal or hepatic impairment. (See Precautions.)
Children: PARIET is not recommended for use in children, as there is no experience of its use in this group.