Adult & elderly Duodenal, gastric & stomal ulcer, reflux esophagitis 10-20 mg once daily. For patients suffering from reflux esophagitis who have not healed after 8 wk, 10 or 20 mg bd for 8 wk may be administered; 20 mg bd for patients w/ severe mucosal injury.
GERD maintenance 10 or 20 mg once daily.
Symptomatic GERD 10 mg once daily in patients w/o esophagitis. Subsequent symptom control can be achieved using an on-demand regimen taking 10 mg once daily when needed.
Zollinger-Ellison syndrome Individualised dosage. A starting dose of 60 mg daily & doses up to 100 mg daily or 60 mg bd have been used.
H. pylori eradication 20 mg bd w/ clarithromycin 500 mg bd & amoxicillin 1 g bd for 1 wk. 10 mg bd w/ clarithromycin 200 mg bd & amoxicillin 750 mg bd for 1 wk. If the above treatment fails, 10 mg bd w/ metronidazole 250 mg bd & amoxicillin 750 mg bd for 1 wk is considered.
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