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Pharmacology: Mydriatic Effect: When ophthalmic solutions containing tropicamide and phenylephrine hydrochloride at various concentrations is applied to the eyes of albino rabbits, mydriasis is produced by relaxation of the iris sphincter muscle by tropicamide and contraction of the iris dilator muscle by phenylephrine hydrochloride. The mydriatic effect was enhanced at the tropicamide-to-phenylephrine ratio of 1:1 by the synergistic effect of both ingredients.
Cycloplegic Effect: This product was applied to the eye once or twice in children with impaired visual acuity or convergent squint for refractometry, and the cycloplegic effect of this product was compared with that of 0.5% or 1% atropine after application 3 times a day for 3 days. This product was weaker in cycloplegic effect than atropine.
Clinical Studies: Mydriatic Effect: In some elderly individuals, who generally have small pupils, adequate mydriasis can not be achieved by topical application of tropicamide alone. It can be achieved by this product containing phenylephrine regardless of age and its effect was particularly remarkable in individuals aged 40 years or more.
Cycloplegic Effect: When 1 drop of this product was applied 3 times every 3 minutes into one eye each of 8 healthy individuals without ophthalmic disease other than refraction disorders, the cycloplegic effect of this product peaked at 20-30 minutes after the last application. Accommodative function returned to normal 5-6 hours after application.
