Domperidone is contraindicated in the following situations: Known hypersensitivity to domperidone or any of the excipients; Prolactin-releasing pituitary tumour (prolactinoma); When stimulation of the gastric motility could be harmful: gastro-intestinal haemorrhage, mechanical obstruction or perforation; In patients with moderate or severe hepatic impairment (see Pharmacology: Pharmacokinetics under Actions); In patients who have known existing prolongation of cardiac conduction intervals, particularly QTc, patients with significant electrolyte disturbances or underlying cardiac diseases such as congestive heart failure (see Precautions); Co-administration with all QT-prolonging drugs, with the exception of apomorphine (see Precautions and Interactions); Co-administration with potent CYP3A4 inhibitors (regardless of their QT-prolonging effects) (see Interactions).
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