Do not apply on irritated skin (including following laser therapy) or open wounds. Discontinue in case of severe irritation or contact allergy; aggravated erythema or flushing. Do not apply close to the eyes. Renal or hepatic impairment. Avoid any increase in the daily amount applied &/or frequency of daily application. Concomitant use w/ other systemic α-adrenergic agonists may potentiate adverse reactions in patients w/ severe or unstable or uncontrolled CV disease; depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension, thrombangiitis obliterans, scleroderma or Sjörgen's syndrome. May cause allergic reactions due to methylparahydroxybenzoate (E218) & skin irritation to propylene glycol. Pregnancy & lactation. Should not be used in childn or adolescents 2-18 yr. Limited study on elderly >65 yr.
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