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Severe Myelosuppression: Advise patients to immediately contact their healthcare provider if they experience signs or symptoms of infection and advise patients to keep all appointments for blood tests. [See Severe Myelosuppression under Precautions.]
Gastrointestinal Toxicity: Advise patients to contact their healthcare provider for severe or persistent nausea, vomiting, diarrhea, or abdominal pain. [See Clinical Trials Experience under Adverse Reactions.]
Administration Instructions: Advise patients that Lonsurf is available in two strengths and they may receive both strength tablets to provide the prescribed dosage.
Advise patients of the importance of reading prescription labels carefully and taking the appropriate number of tablets.
Advise patients to take Lonsurf within 1 hour after eating their morning and evening meals. [See Recommended Dosage under Dosage & Administration.]
Advise patients that anyone else who handles their medication should wear gloves.
Embryo-Fetal Toxicity: Advise pregnant women and females of reproductive potential of the potential risk to the fetus.
Advise females to inform their healthcare provider of a known or suspected pregnancy. [See Embryo-Fetal Toxicity under Precautions; Females and Males of Reproductive Potential under Use in Pregnancy & Lactation.]
Advise female patients of reproductive potential to use effective contraception during treatment with Lonsurf and for at least 6 months after the final dose. [See Embryo-Fetal Toxicity under Precautions; Females and Males of Reproductive Potential under Use in Pregnancy & Lactation.]
Advise males with female partners of reproductive potential to use condoms during treatment with Lonsurf and for at least 6 months after the final dose. [See Females and Males of Reproductive Potential under Use in Pregnancy & Lactation; Pharmacology: Toxicology: Nonclinical Toxicology: Carcinogenesis, Mutagenesis, Impairment of Fertility under Actions.]
Lactation: Advise women not to breastfeed during treatment with Lonsurf and for 1 day following the final dose. [See Lactation under Use in Pregnancy & Lactation.]
