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Instructions for use: The following instructions explain how to give yourself or your child a subcutaneous injection of Humira using the pre-filled syringe/pre-filled pen. First read all the instructions carefully and then follow them step by step.
You will be instructed by your doctor, nurse or pharmacist on the technique of injection.
Do not attempt to inject yourself or your child until you are sure that you understand how to prepare and give the injection.
After proper training, the injection can be given by yourself or your child or given by another person, for example, a family member or friend.
Only use each pre-filled syringe/pre-filled pen for one injection.
Do not use the pre-filled syringe/pre-filled pen and call your doctor or pharmacist if the: liquid is cloudy, discoloured, or has flakes or particles in it; expiry (EXP) date has passed; liquid has been frozen or left in direct sunlight; pre-filled syringe/pre-filled pen has been dropped or crushed.
Do not remove the needle cover/caps until just before injection.
STEP 1: Take Humira out of the refrigerator.
Leave Humira at room temperature for 15 to 30 minutes before injecting.
Do not warm Humira in any other way. For example, do not warm it in a microwave or in hot water.
Pre-filled syringe: Do not remove the needle cover while allowing Humira to reach room temperature.
Pre-filled pen: Do not remove the Grey or Plum-coloured Caps while allowing Humira to reach room temperature.
STEP 2: Check the expiry (EXP) date. Do not use the pre-filled syringe/pre-filled pen if expiry (EXP) date has passed.
Place the following on a clean, flat surface: 1 single-use pre-filled syringe/pre-filled pen and 1 alcohol pad.
Wash and dry your hands.
STEP 3: Choose an injection site: On the front of the thighs; The belly (abdomen) at least 5 cm from the belly button (navel); At least 3 cm from the last injection site.
Wipe the injection site in a circular motion with the alcohol pad.
Do not inject through clothes.
Do not inject into skin that is sore, bruised, red, hard, scarred, has stretch marks, or areas with psoriasis plaques.
STEP 4: Make sure the liquid is clear and colourless.
Do not use the pre-filled syringe/pre-filled pen if the liquid is cloudy or has particles.
Do not use the pre-filled syringe/pre-filled pen if it has been dropped or crushed.
Pre-filled syringe: Hold the pre-filled syringe in one hand.
Check the liquid in the pre-filled syringe.
Gently pull the needle cover straight off with the other hand. Throw the needle cover away. Do not recap.
Do not touch the needle with your fingers or let the needle touch anything.
Pre-filled pen: Hold the pre-filled pen with the Grey Cap 1 pointing up.
Check the inspection window.
It is normal to see 1 or more bubbles in the window.
STEP 5: Pre-filled syringe: Hold the pre-filled syringe with the needle facing up.
Hold the pre-filled syringe at eye level with one hand so you can see the air in the pre-filled syringe.
Slowly push the plunger in to push the air out through the needle.
It is normal to see a drop of liquid at the end of the needle.
Pre-filled pen: Pull the Grey Cap 1 straight off. Throw the cap away. Do not recap.
Check that the small black needle cover of the syringe has been removed with the cap.
It is normal to see a few drops of liquid come out of the needle.
Pull the Plum-coloured Cap 2 straight off. Throw the cap away. Do not recap.
The pre-filled pen is now ready to use.
Turn the pre-filled pen so that the white arrow points toward the injection site.
STEP 6: Squeeze the skin at the injection site with your other hand to make a raised area and hold it firmly.
Pre-filled syringe: Hold the body of the pre-filled syringe in one hand between the thumb and index fingers, like you would a pencil.
Pre-filled pen: Point the white arrow toward the injection site (thigh or abdomen).
Place the white needle sleeve straight (90° angle) against the injection site.
Hold the pre-filled pen so that you can see the inspection window.
STEP 7: Pre-filled syringe: Insert the needle all the way into the skin at about a 45-degree angle with one quick, short motion.
After the needle is in, let go of the skin you are holding.
Slowly push the plunger all the way in until all of the liquid is injected and the pre-filled syringe is empty.
Pre-filled pen: Push and keep pushing the pre-filled pen down against the injection site.
Press the plum activator button and count slowly for 10 seconds.
A loud "click" will signal the start of the injection.
Keep pushing the pre-filled pen down against the injection site.
The injection is complete when the yellow indicator has stopped moving.
STEP 8: After completing the injection, place a cotton ball or gauze pad on the skin over the injection site.
Do not rub.
Slight bleeding at the injection site is normal.
Pre-filled syringe: When the injection is completed, slowly pull the needle out of the skin while keeping the pre-filled syringe at the same angle.
Pre-filled pen: When the injection is completed, slowly pull the pre-filled pen from the skin. The white needle sleeve will cover the needle tip.
If there are more than a few drops of liquid on the injection site, contact your doctor, nurse or pharmacist.
STEP 9: Throw away the used pre-filled syringe/pre-filled pen in a special disposal container as instructed by your doctor, nurse or pharmacist. Never recap a needle.
Do not recycle or throw the pre-filled syringe/pre-filled pen in the household waste.
Always keep the pre-filled syringe/pre-filled pen and the special disposal container out of the sight and reach of children.
The needle cover/caps, alcohol pad, cotton ball or gauze pad, blister and packaging may be put in your household waste.
