The 1st 20-30 mL should be infused slowly & under careful observation of the patient.
Compensation of minor losses of blood or plasma, pre- & intra-operative routine prophylaxis 500-1,000 mL infused over 1-3 hr.
Major losses of blood or plasma Average dose is between 1,000 & 2,000 mL.
Emergency situations or shock conditions Initially 500 mL administered by forced infusion over 5-10 min. Thereafter, the infusion can be continued w/ doses corresponding to actual losses of blood or plasma.
Isovolaemic haemodilution Amount of infused soln corresponds to the w/drawn plasma vol. Dose should not exceed 20 mL/kg.
During extracorporal circulation Normally, between 500 & 1,000 mL.
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