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DIPROSPAN Suspension is a combination of soluble and very slightly soluble betamethasone esters that provides potent anti-inflammatory, antirheumatic and antiallergic effects in the treatment of corticosteroid-responsive disorders. Prompt therapeutic activity is achieved by the soluble ester, betamethasone disodium phosphate, which is absorbed quickly after injection. Sustained activity is provided by betamethasone dipropionate, which is only slightly soluble and becomes a repository for slow absorption, thereby controlling symptoms over a prolonged period. The small crystal size of betamethasone dipropionate permits the use of a fine-gauge needle (up to 26 gauge) for intradermal and intralesional administration.
Glucocorticosteroids, such as betamethasone, cause profound and varied metabolic effects and modify the body's immune response to diverse stimuli.
Betamethasone has high glucocorticosteroid activity and slight mineralocorticosteroid activity.
