Dicofen Drug Interactions

Inadvisable Concomitant Medications: Other NSAIDs; oral anticoagulants, heparin via parenteral route and ticlopidine; intrauterine device (IUD): Possible diminution of efficacy; lithium (if necessary, closely monitor lithium levels and adopt lithium dosage during concomitant use and after the end of NSAID treatment); methotrexate used at doses >15 mg weekly: Increase in methotrexate haematological toxicity; digoxin.
Concomitant Medications Requiring Precautions for Use: Diuretics: Risk of acute renal failure in the dehydrated patient by decreased glomerular filtration. Rehydrate the patient and monitor renal function during initiation of treatment.
Methotrexate Used at Low Doses (< 15 mg weekly): Weekly monitoring of haematological function during the first weeks of concomitant medications.
Pentoxifylline: Increased risk of haemmorhage.
Concomitant Medications to be Taken into Account: Antihypertensive (β-Blockers, ACE Inhibitors, Diuretics): Reduction of the antihypertensive action.
Interferon-α: Risk of inhibition of action.
Thrombolytic Drugs: Increased risk of haemorrhage.