Concomitant treatment w/ MAOIs. Should be used w/ caution in patients w/ organic brain syndrome, convulsion, urinary retention, hyperthyroidism & advanced hepatic or CV disease, in susceptible individuals & in patients w/ a history of CV disorders. Concomitant treatment w/ other drugs which may cause QT prolongation is contraindicated. Serotonergic psychiatric drugs should not be started in a patient receiving linezolid. Wait until 24 hr after the last dose of linezolid before starting the serotonergic psychiatric drugs. Not recommended for excitable or overactive patients. The possibility of development of NMS. Depression is associated w/ an increased risk of suicidal thoughts, self-harm & suicide. It is a general clinical experience that the risk of suicide may increase in the early stages of recovery. Close supervision of high-risk patients should accompany drug therapy. Patients (& caregivers) should be alerted about the need to monitor for any clinical worsening, suicidal behaviour or thoughts & unusual changes in behaviour & to seek medical advice immediately if these symptoms present. Deanxit may modify insulin & glucose responses. In patients w/ the rare condition of shallow anterior chamber & narrow chamber angle, attacks of acute glaucoma due to dilation of the pupil may be provoked. Deanxit should be used w/ caution in patients receiving SSRIs, w/ risk factors for stroke. Increased mortality in older people w/ dementia. Deanxit is not licensed for the treatment of dementia-related disturbances. Anaesth given during tri/tetracyclic antidepressant therapy may increase the risk of arrhythmias & hypotension. Cases of VTE have been reported w/ antipsychotic drugs. Not recommended in childn & adolescents <18 yr.
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