Pentoxifylline may potentiate the effect of anti-hypertensive agents and the dosage of the latter may need to be reduced.
Pentoxifylline should not be given concomitantly with ketorolac as there is increased risk of bleeding and/or prolongation of prothrombin time.
Concomitant administration of pentoxifylline and theophylline may increase theophylline levels in some patients. Therefore there may be increase in and intensification of adverse effects of theophylline.