Carboplatin-Tranet Side Effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.
Immediate medical attention is necessary in case of the following: Abnormal bruising, bleeding, or signs of infection such as a sore throat and high temperature; Severe allergic reaction (anaphylaxis/anaphylactic reactions) (patients may experience a sudden itchy rash (hives), swelling of the hands, feet, ankles, face, lips, mouth or throat which may cause difficulty in swallowing or breathing, and patients may feel they are going to faint); Muscle cramping, muscle weakness, confusion, visual loss or disturbances, irregular heartbeat, kidney failure or abnormal blood test results (symptoms of tumor lysis syndrome which can be caused by the rapid breakdown of tumour cells) (see Precautions).
These are serious side effects. Patients may need urgent medical attention.
Very common (may affect more than 1 in 10 people): Myelosuppression; Tiredness, shortness of breath and paleness caused by anaemia; Increase in the level of urea in the blood; Abnormal liver enzyme levels; Nausea or vomiting; Stomach pain and cramp; Decrease in the level of sodium, potassium, calcium and magnesium in the blood; Decrease in renal creatinine clearance.
Common (may affect up to 1 in 10 people): Diarrhoea or constipation; Rash and/or itchy skin; Ringing in the ears or changes in hearing; Hair loss; Flu-like symptoms; Signs of infection such as fever or sore throat; Symptoms of severe allergic reaction including sudden wheeziness or tightness of chest, swelling of the eyelids, face or lips, facial flushing, low blood pressure, rapid heartbeat, hives, shortness of breath, dizziness and anaphylactic shock; Tingling or numbness in the hands, feet, arms or legs; Burning or prickling sensation; Decreased tendon reflex; Taste disturbance or loss of taste; Temporary worsening of eyesight or changes to the vision; Heart disorders; Tightness of the chest or wheezing; Interstitial lung disease; Sore lips or mouth ulcers (mucous membrane disorders); Pain or discomfort in the bones, joints, muscles, or surrounding structures (musculoskeletal disorder); Problems with the kidneys or urine; Asthenia; Increased level of bilirubin and creatinine in the blood; Increased level of uric acid in the blood which may lead to gout.
Rare (may affect up to 1 in 1,000 people): Temporary sight loss; Febrile neutropenia.
Very rare (may affect up to 1 in 10,000 people): Pulmonary fibrosis.
Not known (frequency cannot be estimated from the available data): Secondary malignancies; Haemolytic uraemic syndrome; Dry mouth, tiredness, and headache due to dehydration; Loss of appetite, anorexia; Stroke; Severely impaired liver function, damage or death of liver cells; Heart failure; Embolism; Hypertension or hypotension; Skin disorders such as hives, rash, erythema, and itching; Swelling or soreness where the injection was given; Group of symptoms such as headache, altered mental functioning, seizures and abnormal vision from blurriness to vision loss (symptoms of reversible posterior leukoencephalopathy syndrome); Pancreatitis; Stomatitis; Lung infection.
Carboplatin may lead to problems with the blood, liver and kidneys. Blood samples should be taken to check for these problems.
Reporting of side effects: Side effects should be reported. This includes any possible side effects not previously listed.