Myelosuppression; tiredness, shortness of breath & paleness caused by anaemia; increased blood urea level; abnormal liver enzyme levels; nausea or vomiting; stomach pain & cramp; decrease in the blood level of Na, K, Ca, & Mg; decrease in renal CrCl. Diarrhoea or constipation; rash &/or itchy skin; ringing in the ears or changes in hearing; hair loss; flu-like symptoms; signs of infection; symptoms of severe allergic reaction; tingling or numbness in hands, feet, arms or legs; burning or prickling sensation; decreased tendon reflex; taste disturbance or loss of taste; temporary worsening of eyesight or changes to vision; heart disorders; tightness of the chest or wheezing; ILD; mucous membrane disorders; musculoskeletal disorder; problems w/ kidneys or urine; asthenia; increased blood level of bilirubin, creatinine, uric acid.