Beprosalic Mechanism of Action

Lotion: Betamethasone dipropionate is a topically active fluorinated corticosteroid which has anti-inflammatory, anti-pruritic and vasoconstrictive actions. Salicylic Acid has keratolytic properties, as well as bacteriostatic and fungicidal actions.
Pharmacology: Topical corticosteroids have anti-inflammatory, anti-pruritic and vasoconstrictive actions. When administered topically, particularly under occlusive dressing or when the skin is broken, sufficient corticosteroid may be absorbed to give systemic effects. Corticosteroids are extensively bound to plasma proteins. Only unbound corticosteroids has pharmacological effects or is metabolised. They are metabolised mainly in the liver, also in the kidney and are excreted in the urine. Salicylic Acid has keratolytic properties. It produces slow and painless destruction of the epithelium. When administered topically to large areas of the body, it may cause symptoms of acute systemic salicylate poisoning.
Ointment: Pharmacodynamics: Betamethasone dipropionate is a topically active fluorinated corticosteroid which has anti-inflammatory, anti-pruritic and vasoconstrictive actions. Salicylic acid has keratolytic properties, as well as bacteriostatic and fungicidal actions.
Pharmacokinetics: When applied topically, particularly to large areas, when the skin is broken, or under occlussive dressings, corticosteroids may be absorbed in sufficient amounts to cause systemic effects. Most corticosteroids in the circulation are extensively bound to plasma proteins. They are metabolized mainly in the liver but also on other tissues, and are excreted in the urine. Salicylic acid is readily absorbed through the skin and symptoms of acute systemic salicylate poisoning have been reported after excessive use.