Asacol Adverse Reactions

Dose-dependent hypersensitivity reactions such as fever¹, bronchospasm¹ or alopecia¹ can occur rarely¹. Alopecia can also be a rare extra-intestinal manifestation of chronic inflammatory bowel disease. Other rare¹ adverse reactions are predominantly gastrointestinal, including diarrhoea and abdominal pain.
Adverse reactions which occur rarely very rarely² are listed by system organ class.
Blood and lymphatic: Blood dyscrasia, bone marrow depression with leukopenia, neutropenia, thrombocytopenia, pancytopenia up to aplastic anemia.
Nervous system: Headache, vertigo, arthralgia.
Cardiac: Myocarditis, pericarditis.
Muscles: Myalgia.
Respiratory: Allergic lung reactions, bronchospasm, eosinophilic penumonia.
Digestive: Nausea, vomiting, pancreatitis, hepatitis, exacerbation of the symptoms of colitis.
Skin and appendages: Mesalazine-induced lupus-erythematodes-like symptoms with pericarditis and pleuroperi-carditis as prominent symptoms as well as rash and arthralgia.
Renal & urinary: Interstitial nephritis, nephrotic syndrome. Renal failure, which may be reversible on withdrawal.
Patients should immediately inform their physician if they experience any of these changes or other signs of illness.
¹rare: one adverse reaction in 1000 to 10,000 treatment years.
²very rare: less than one adverse reaction per 10,000 treatment years.