Posology: The recommended adult dose is one 5 mg tablet daily, with or without food.
Finasteride can be administered alone or in combination with the alpha-blocker doxazosin.
Although early improvement in symptoms may be seen, treatment for at least six months may be necessary to assess whether a beneficial response has been achieved. The risk of acute urinary retention is reduced within four months of treatment.
Dosage in the elderly: Dosage adjustments are not necessary although pharmacokinetic studies have shown that the elimination rate of finasteride is slightly decreased in patients over the age of 70.
Dosage in hepatic insufficiency: The effect of hepatic insufficiency on the pharmacokinetics of finasteride has not been studied.
Dosage in renal insufficiency: No adjustment in dosage is required in patients with varying degrees of renal insufficiency (creatinine clearances as low as 9 mL/min), as pharmacokinetic studies did not indicate any change in the disposition of finasteride.
Paediatric population: Finasteride is contraindicated in children.
Method of administration: Finasteride is for oral use only.