Methylprednisolone aceponate.
1 g Advantan contains 1 mg (0.1%) methylprednisolone aceponate.
After topical application, Advantan suppresses inflammatory and allergic skin reactions as well as reactions associated with increased cellular regeneration, leading to regression of the objective symptoms (erythema, oedema, thickening of the skin, coarseness of the skin surface) and the subjective complaints (itching, burning, pain).
Endogenous eczema (atopic dermatitis, neurodermatitis), contact eczema, degenerative, dyshidrotic, vulgar eczema, eczema in children.
Unless otherwise prescribed by the doctor, the Advantan formulation appropriate to the skin condition is applied thinly once per day to the diseased areas of skin.
In general, the duration of use should not exceed 12 weeks in adults and 4 weeks in children.
Advantan cream: As a low-fat formulation with a high water content, Advantan cream is particularly suitable for acute and weeping stages of eczema, for very greasy skin and for use on exposed or hairy parts of the body.
Advantan ointment: Skin conditions which are neither weeping nor very dry require a base with balanced proportions of fat and water. Advantan ointment makes the skin slightly greasy without retaining warmth and fluid. Of the formulations, Advantan ointment has the widest field of use.
Tuberculous or syphilitic processes in the area to be treated; virus diseases (e.g. vaccinia, children-pox, shingles). The clinical indication for treatment with Advantan must be carefully reviewed and the benefits weighed against the risks in pregnant and lactating women. In particular, large-area or prolonged use must be avoided.
Additional, specific therapy is required in bacterially infected skin diseases and/or in fungus infections.
If the skin dries out excessively under protracted use of Advantan cream, a switch should be made to the fattier formulation (e.g. Advantan ointment).
Advantan should not be allowed to come into contact with the eyes when being applied to the face.
If rosacea or perioral dermatitis is present, Advantan must not be applied to the face.
No impairment of adrenocortical function has been observed either in adults or in children on large-area (40% to 60% of the skin surface) or even occlusive treatment with Advantan. Nevertheless, the duration of use should be kept as brief as possible on treatment of large areas.
Local concomitant symptoms such as itching, burning, erythema or vesiculation may occur in isolated cases under treatment with Advantan.
Thinning of the skin (atrophy), dilatation of cutaneous vessels (telangiectasias), the formation of stripes (striae) or acneiform skin conditions can occur under therapy with potent corticoids. During the clinical investigation, none of these side effects occurred under Advantan on treatment up to 12 weeks (adults) and 4 weeks (children).
As with other corticoids for topical use, the following side effects may occur in rare cases: Folliculitis, increased growth of body hair (hypertrichosis), perioral dermatitis, allergic skin reactions to one of the ingredients of the formulations.
D07AC14 - methylprednisolone aceponate ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.
Advantan cream 0.1 %
15 g x 1's
Advantan oint 0.1 %
15 g x 1's
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