Đăng xuất
Pharmacokinetics: Following oral administration, 87-100% of the dose is excreted in the faeces, up to 75% as parent compound depending on the dose. There is one poorly active major metabolite.
Following IV administration, there is rapid plasma clearance suggestive of extensive hepatic extraction. The plasma elimination half-life is approximately 3 hrs. The volume of distribution is approximately 260 L.
Fluticasone propionate causes little or no hypothalamic-pituitary-adrenal (HPA) axis suppression following intranasal or topical (dermal) administration.
